For many years pseudoephedrine was available as an over-the-counter treatment for a congested nose from allergies or the common cold. However, it was moved behind the counter when it was misused to make an addicting drug.
That meant that phenylephrine was the only medication available over-the-counter for the oral treatment of nasal congestion.
Phenylephrine is effective when used directly into the nose (intranasal). It has also been available in an oral form.
Recently, the FDA reviewed research on the safety and effectiveness of the oral form. They have concluded that it is safe if taken at approved doses.
However, the FDA also concluded that multiple studies show that it is INEFFECTIVE. That is, it does not reduce nasal congestion any more than a placebo (an inactive ingredient for comparison with the medicine being tested).
If they are correct, then purchasing an over-the-counter oral decongestant with phenylephrine would not be helpful.
Peter M. Hartmann, MD
Family Medicine & Psychiatry
